- Tabrizi et al., The Lancet Neurology 2009; 8: .791-801: "Analysis of the quantitative motor ... data was done automated, blinded, and free from bias."
- "The most sensitive outcome measures identified in die quantitative motor assessments can be tested within 5 min in each individual."
- "All techniques are portable and can be used in an out-patient setting by trained technicians."
- "Therefore, the use of these techniques is not restricted to specialized centers, but can easily be established in studies with many sites, with relatively low costs for equipment, maintenance, and assessment of blinded data."
- Biglan, Neurology 2010; 75: 2142-3: "... a quantitative motor task that links function and structure and distinguishes healthy controls from gene-positive individuals prior to disease onset through early stages of manifest HD..."
- "These findings suggest a path forward to designing therapeutic trials aimed at showing an effect on delaying onset in preHD or in slowing progression in early HD."
- "Finally, select quantitative tapping variables were associated with gray matter atrophy and cortical thinning on volumetric brain imaging, demonstrating a link between a reproducible quantitative motor task, clinical function, and structural changes in HD."
- "... suggesting that the quantitative motor task may be a more sensitive measure of motor impairment in pre and early HD [than a clinical rating scale]."